Blood Cross Matching Procedure

Blood cross matching procedure is among the most premier blood test. It is must to do before blood transfusion. It is essential to find; is the donor’s blood is compatible with recipient or not?  Moreover, it should be done prior to organ transplants. Blood cross matching is quite technical that it must be done by a certified laboratory technologist. Now with modern techniques, laboratories have used several methods for it which include serologically, screen for antibodies or indirect Coombs test etc.
The most common and easiest is serological blood cross matching procedure. In this method red blood cells from the donor blood are tested against the serum part of the patient’s blood. If agglutination will occur it shows that patient’s serum contains same antibodies against donor red blood cells antigens. This agglutination will be considered a positive indication that donor unit is highly incompatible with that specific patient. In case, if there is no agglutination occurred, this unit blood is deemed compatible to transfuse to patients.
Blood cross matching procedure falls into two categories:

1. Major Cross-match:

In this blood cross matching procedure the recipient serum is tested with the donor packed cells. It will help to determine that if the recipient antibodies possess antigens against donor’s cells. This is more reliable than minor blood cross matching procedure.

2. Minor Cross-match:

In minor blood cross matching procedure the recipient red cells are combined with donor serum, it helps to detect whether donor serum possesses antibodies against patient’s antigens.

I select to write on blood cross matching procedure, because one must know regarding this to prevent any sort of complication during blood transfusion. I write over it because I want to provide maximum health care for you.

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